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ea0090p425 | Pituitary and Neuroendocrinology | ECE2023

Longitudinal multiomics characterization of paired primary and recurrent aggressive pituitary tumors from the same patient reveals genomic stability and transcriptomic and epigenetic heterogeneity with metabolic pathways alterations

Taniguchi Keiko , Chavez-Santoscoy Alejandra , Hinojosa-Alvarez Silvia , Hernandez-Perez Jesus , Valenzuela-Perez Alejandra , Vela Patino Sandra , Andonegui-Elguera Sergio , Cano-Zaragoza Amayrani , Martinez Florencia , Kerbel Jacobo , Zhang Zidong , Smith Gergory , Rubenstein Aliza , Sze Cheng Wan , Mendelev Natalia , Anne Amper Mary , Zamojski Michel , Zaslavsky Elena , Ruf-Zamojski Frederique , Sealfon Stuart , Mercado Moises , Marrero-Rodriguez Daniel

Pituitary tumors (PT) represent 20% of all intracranial neoplasms. Some behave aggressively, growing rapidly and invading surrounding tissues, with high recurrence rates and are frequently resistant to conventional therapies. We performed exome and transcriptome sequencing, as well as methylation profiling of primary and recurrent PT of the same patient. The cohort consisted of patients with GH- and gonadotropin-producing PT and a patient with an ACTH carcinom...

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Endocrine Abstracts

Longitudinal multiomics characterization of paired primary and recurrent aggressive pituitary tumors from the same patient reveals genomic stability and transcriptomic and epigenetic heterogeneity with metabolic pathways alterations

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